Porcelain gallbladder is associated with an increased risk of which condition?

Porcelain gallbladder is associated with an increased risk of which condition?

• A. Pancreatic cancer
• B. Gallbladder adenocarcinoma
• C. Esophageal cancer
• D. Liver metastasis

Answer: (B)

Porcelain gallbladder is calcification of the gallbladder wall from long-standing inflammation. This finding carries an elevated risk of gallbladder cancer, most commonly gallbladder adenocarcinoma. The chronic inflammatory milieu can drive dysplastic changes in the gallbladder lining, increasing malignant transformation. Therefore, the association is with gallbladder adenocarcinoma. The other cancers listed do not have a specific, known link to porcelain gallbladder. In practice, this cancer risk often leads clinicians to consider removing the gallbladder even if symptoms are absent.

Porcelain gallbladder is calcification of the gallbladder wall from long-standing inflammation. This finding carries an elevated risk of gallbladder cancer, most commonly gallbladder adenocarcinoma. The chronic inflammatory milieu can drive dysplastic changes in the gallbladder lining, increasing malignant transformation. Therefore, the association is with gallbladder adenocarcinoma. The other cancers listed do not have a specific, known link to porcelain gallbladder. In practice, this cancer risk often leads clinicians to consider removing the gallbladder even if symptoms are absent.