35-year-old patient with necrolytic erythema and metabolic symptoms is most likely diagnosis?

35-year-old patient with necrolytic erythema and metabolic symptoms is most likely diagnosis?

• A. Pheochromocytoma
• B. Glucagonoma
• C. Carcinoid syndrome
• D. Hyperparathyroidism

Answer: (B)

Necrolytic migratory erythema is strongly associated with a glucagon-secreting pancreatic tumor. Excess glucagon drives a hyperglycemic, catabolic state with weight loss and metabolic disturbances, and the characteristic skin eruption—red, blistering patches that migrate, often around the perioral region, trunk, and groin—points toward a glucagonoma. The other conditions listed produce different symptom patterns (hypertension and headaches for pheochromocytoma; flushing/diarrhea for carcinoid; hypercalcemia-related symptoms for hyperparathyroidism) and do not explain the necrolytic erythema.

Necrolytic migratory erythema is strongly associated with a glucagon-secreting pancreatic tumor. Excess glucagon drives a hyperglycemic, catabolic state with weight loss and metabolic disturbances, and the characteristic skin eruption—red, blistering patches that migrate, often around the perioral region, trunk, and groin—points toward a glucagonoma. The other conditions listed produce different symptom patterns (hypertension and headaches for pheochromocytoma; flushing/diarrhea for carcinoid; hypercalcemia-related symptoms for hyperparathyroidism) and do not explain the necrolytic erythema.